Polarized secretion of interleukin (IL)-6 and IL-8 by human airway epithelia 16HBE14o- cells in response to cationic polypeptide challenge.
BACKGROUND: The airway epithelium participates in asthmatic inflammation in many ways.Target cells of the epithelium can respond to a variety of inflammatory mediators and cytokines.Damage to the surface epithelium occurs following the secretion of eosinophil-derived, highly toxic cationic proteins.Moreover, the surface epithelium itself is respons